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Review
. 2002 Aug;12(4):403-8.
doi: 10.1016/s0959-437x(02)00317-9.

Iroquois genes: genomic organization and function in vertebrate neural development

José Luis Gómez-Skarmeta  1 , Juan Modolell
Affiliations
Review

Iroquois genes: genomic organization and function in vertebrate neural development

José Luis Gómez-Skarmeta et al. Curr Opin Genet Dev. 2002 Aug.

Abstract

We review recent work that shows that the iroquois (Iro/Irx) homeobox genes have conserved genomic organization in Drosophila and vertebrates. In addition, these genes play pivotal functions in the initial specification of the vertebrate neuroectoderm, and, in collaboration with other transcription factors, later subdivision of the anterior-posterior and dorso-ventral axis of the neuroectoderm.

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