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Case Reports
. 2002 Jul;55(7):541-2.
doi: 10.1136/jcp.55.7.541.

Ductal carcinoma in situ arising in mammary hamartoma

G M K Tse  1 , B K B Law, L M Pang, H S Cheung
Affiliations
Case Reports

Ductal carcinoma in situ arising in mammary hamartoma

G M K Tse et al. J Clin Pathol. 2002 Jul.

Abstract

Hamartoma of the breast is an uncommon lesion. Although it can possess characteristic radiological features, the pathological appearance is not distinctive. Hamartoma is generally considered benign, but four cases have been reported with ductal and lobular carcinoma arising in hamartomas. This report describes further cases of hamartoma from which ductal carcinoma in situ arose, with one showing early invasion. In both cases, the tumours were within the hamartomas and were adequately excised during lumpectomies of the hamartomas, and the patients were well afterwards. This report emphasises the importance of adequate sampling of mammary hamartoma.

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Figures

Figure 1
Figure 1
Low power photomicrograph of case 2 showing a hamartoma with rounded border and a fibrous capsule. Haematoxylin and eosin stained.
Figure 2
Figure 2
A focus of ductal carcinoma in situ in case 2 with solid and cribriform pattern. Normal lobules are seen at the edge of the picture (asterisks). Haematoxylin and eosin stained.
Figure 3
Figure 3
A focus of ductal carcinoma in situ of solid type in case 2. Isolated tumour clusters are seen free in the stroma within a mucinous background. Microcalcification is also noted (arrow). Haematoxylin and eosin stained.
See this image and copyright information in PMC

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