Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2002 Apr;31(2):185-9.
doi: 10.1054/ijom.2001.0193.

Differences in mandibular distraction osteogenesis after corticotomy and osteotomy

J Hu  1 , J Li, D Wang, M J Buckley, S Agarwal
Affiliations
Comparative Study

Differences in mandibular distraction osteogenesis after corticotomy and osteotomy

J Hu et al. Int J Oral Maxillofac Surg. 2002 Apr.

Abstract

Corticotomy or osteotomy was performed on opposing sides of the mandibles in 18 goats. A custom-made distractor was used to lengthen the mandible at a rate of 1 mm/day for 10 days (total 10 mm elongation). Six goats were sacrificed respectively at 2, 4 and 8 weeks after completion of distraction. The distracted calluses were harvested and processed for radiographic, histologic, and scanning electron microscopic evaluation as well as Ca/P ratio analysis. The regenerate bone in the corticotomy side showed more bone formation and earlier mineralization than in the osteotomy side. The results of this study suggest that preservation of intramedullary vessels is beneficial to bone regeneration following mandibular osteodistraction, and that performing corticotomy may be a simple but effective way to promote the maturity of the distracted callus and shorten the time for fixation.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Mandibular radiographs at sacrifice, showing the differences in radiodensity between the corticotomy (CO) and the osteotomy (OS) sides. Note greater formation of periosteal callus (arrows) on the osteotomy sites at 4 and 8 weeks’ postdistraction. (A) 2 weeks. (B) 4 weeks. (C) 8 weeks.
Fig. 2
Fig. 2
Histological photomicrographs of the regenerate bone in the distraction gap. (A) Corticotomy—2 weeks (HE×40). (B) Osteotomy—2 weeks (HE×40). (C) Corticotomy—4 weeks (HE×40). (D) Osteotomy—4 weeks (HE×40). (E) Corticotomy—8 weeks (HE×100), showing that mature lamellar bone and fatty marrow filled the newly reformed medullary cavity.
Fig. 3
Fig. 3
SEM photomicrographs of regenerate bone in the centre of the distraction gap. (A) Corticotomy—2 weeks (original magnification ×50). (B) Osteotomy—2 weeks (original magnification ×50). (C) Corticotomy—4 weeks (original magnification ×200). (D) Osteotomy—4 weeks (original magnification ×200). (E) Corticotomy—8 weeks (original magnification ×200). (F) Osteotomy—8 weeks (original magnification × 50). Note an interface and some differences in density between the new bone (NB) and the original bone (OB).
See this image and copyright information in PMC

References

    1. Alberius P, Isaksson S, Klinge B, Sjogren S, Jonsson J. Regeneration of cranial suture and bone plate lesions in rabbits. J Craniomaxillofac Surg. 1990;18:271–279. - PubMed
    1. Cancedda R, Descalzi CF, Castagnola P. Chondrocyte differentiation. Int Rev Cytol. 1995;159:265–358. - PubMed
    1. Costantino PD, Shybut G, Friedman CD, Pelzer HJ, Masini M, Shindo ML, Sisson GA. Segmental mandibular regeneration by distraction osteogenesis. Arch Otolaryngol Head Neck Surg. 1990;119:535–545. - PubMed
    1. Ganey TM, Klotch DW, Slater-Haase AS, Sasse J. Evaluation of distraction osteogenesis by scanning electron microscopy. Otolaryngol Head and Neck Surg. 1994;111:265–272. - PubMed
    1. Hagiwara T, Bell WH. Effect of electrical stimulation on mandibular distraction osteogenesis. J Craniomaxillo Surg. 2000;28:12–19. - PubMed

Publication types

LinkOut - more resources