doi: 10.1111/j.1460-9568.1989.tb00780.x.
Noradrenaline-Induced Inhibition of Voltage-Sensitive Calcium Currents in NG108-15 Hybrid Cells
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- PMID: 12106162
- DOI: 10.1111/j.1460-9568.1989.tb00780.x
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Noradrenaline-Induced Inhibition of Voltage-Sensitive Calcium Currents in NG108-15 Hybrid Cells
Eur J Neurosci.
1989 Mar.
Abstract
The effect of noradrenaline (NA) on voltage-sensitive calcium currents in neuroblastoma x glioma hybrid (NG108-15) cells has been studied using a whole-cell clamp technique. NA inhibited calcium current. The EC50 for NA induced inhibition was 177 nM. The NA receptor involved had a similar pharmacological profile to alpha2 adrenoreceptors but did not respond to clonidine. NA inhibited calcium current by an amount which dependend on both membrane potential and current amplitude. When current-dependent inactivation of calcium current was maximal, NA was without effect. The data are consistent with a mechanism where NA enhances current-dependent inactivation.
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