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Review
. 2002 Jul;4(9):887-95.
doi: 10.1016/s1286-4579(02)01615-5.

Genetic approaches to the study of Toll-like receptor function

Osamu Takeuchi  1 , Shizuo Akira
Affiliations
Free article
Review

Genetic approaches to the study of Toll-like receptor function

Osamu Takeuchi et al. Microbes Infect. 2002 Jul.
Free article

Abstract

The Toll-like receptor (TLR) family plays a role in sensing invading pathogens. Ten members have been reported to date, seven of which were found to recognize discrete bacterial components. Mouse models lacking each TLR and its signaling molecule are useful tools for the analysis of the innate immune system.

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