[Fatal miliary tuberculosis during treatment with infliximab]
- PMID: 12109312
[Fatal miliary tuberculosis during treatment with infliximab]
Abstract
A 73-year-old woman was admitted to hospital with fever whilst under treatment with infliximab for rheumatoid arthritis. Despite repeated and specific testing, tuberculosis was only diagnosed post mortem. During infliximab therapy, latent tuberculosis can reactivate in subacute form with a possible fatal outcome. For infliximab therapy to be administered safely, the risk that the patient concerned is latently infected with tuberculosis has to be estimated beforehand; if necessary a prophylactic anti-tuberculosis treatment may be given.
Comment in
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[The treatment of chronic inflammatory diseases with monoclonal antibodies against tumor necrosis factor: side effects, contraindications and precautions].Ned Tijdschr Geneeskd. 2002 Jun 22;146(25):1165-8. Ned Tijdschr Geneeskd. 2002. PMID: 12109305 Review. Dutch.