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Review
. 2002 Jun;25(3):213-31.
doi: 10.1385/MN:25:3:213.

Tau function and dysfunction in neurons: its role in neurodegenerative disorders

Jesús Avila  1 , Filip Lim, Francisco Moreno, Carlos Belmonte, A Claudio Cuello
Affiliations
Review

Tau function and dysfunction in neurons: its role in neurodegenerative disorders

Jesús Avila et al. Mol Neurobiol. 2002 Jun.

Abstract

Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.

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References

    1. Nature. 1999 Jun 24;399(6738):784-8 - PubMed
    1. J Biochem. 1987 Dec;102(6):1415-21 - PubMed
    1. J Biol Chem. 1992 Aug 5;267(22):15721-8 - PubMed
    1. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1101-18 - PubMed
    1. J Neurochem. 2000 Jun;74(6):2583-9 - PubMed

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