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Review
. 2002;4 Suppl 2(Suppl 2):S1-5.
doi: 10.1186/ar551. Epub 2002 Apr 26.

Autoantibodies in rheumatoid arthritis and their clinical significance

Günter Steiner  1 , Josef Smolen
Affiliations
Review

Autoantibodies in rheumatoid arthritis and their clinical significance

Günter Steiner et al. Arthritis Res. 2002.

Abstract

Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. However, a highly specific marker autoantibody for rheumatoid arthritis (RA) has not yet been determined. The presence of rheumatoid factors is currently used as a marker for RA. However, rheumatoid factors have modest specificity (~70%) for the disease. In recent years, several newly characterized autoantibodies have become promising candidates as diagnostic indicators for RA. Antikeratin, anticitrullinated peptides, anti-RA33, anti-Sa, and anti-p68 autoantibodies have been shown to have >90% specificity for RA. These autoantibodies are reviewed and the potential role of the autoantibodies in the pathogenesis of RA is briefly discussed.

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