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Review
. 2002 Jul;3(1):1-2.
doi: 10.1016/s1534-5807(02)00210-1.

BiP binding keeps ATF6 at bay

Thomas Sommer  1 , Ernst Jarosch
Affiliations
Free article
Review

BiP binding keeps ATF6 at bay

Thomas Sommer et al. Dev Cell. 2002 Jul.
Free article

Abstract

A study by, in this issue of Developmental Cell shows that transport to the Golgi complex and subsequent proteolytic activation of the stress-regulated transcription factor ATF6 is initiated by the dissociation of the ER chaperone BiP from ATF6. This demonstrates that BiP is a key element in sensing the folding capacity within the ER and provides mechanistic insights on how the activation of membrane-bound transcription factors can be regulated.

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