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Review
. 2002 Jul;3(1):6-7.
doi: 10.1016/s1534-5807(02)00213-7.

Genetics leads the way to the accomplices of presenilins

Caroline Goutte  1
Affiliations
Free article
Review

Genetics leads the way to the accomplices of presenilins

Caroline Goutte. Dev Cell. 2002 Jul.
Free article

Abstract

Presenilins mediate the gamma-secretase cleavage of Notch transmembrane receptors as well as the transmembrane beta-amyloid precursor protein (betaAPP), but they are not thought to accomplish this alone. Recent genetic screens in C. elegans, presented in this issue of Developmental Cell, identify two genes that are essential to gamma-secretase activity and may interact with presenilins.

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