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. 2002 Sep;10(9):2981-5.
doi: 10.1016/s0968-0896(02)00130-x.

CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper

Sachiko Tsukamoto  1 , Kyoko Tomise, Keiko Miyakawa, Bae-Cheon Cha, Takamasa Abe, Toshiyuki Hamada, Hiroshi Hirota, Tomihisa Ohta
Affiliations

CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper

Sachiko Tsukamoto et al. Bioorg Med Chem. 2002 Sep.

Abstract

Two new bisalkaloids, dipiperamides D and E, were isolated as inhibitors of a drug metabolizing enzyme cytochrome P450 (CYP) 3A4 from the white pepper, Piper nigrum. Their structures were elucidated by spectroscopic methods. Dipiperamides D and E showed potent CYP3A4 inhibition with IC(50) values of 0.79 and 0.12 microM, respectively, and other metabolites from the pepper were moderately active or inactive.

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