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. 1975 Dec 19;33(3):185-90.
doi: 10.1007/BF00688392.

Acute lead encephalopathy in the guinea pig

T W Bouldin, M R Krigman

Acute lead encephalopathy in the guinea pig

T W Bouldin et al. Acta Neuropathol. .

Abstract

Acute lead encephalopathy was induced in adult guinea pigs with daily oral doses of lead carbonate. Cerebral capillaries were examined by electron microscopy, and the blood-brain barrier (B-BB) evaluated with Evans blue and horseradish peroxidase. Brain lead levels were also determined during the developing encephalopathy. There was no cerebral capillary alteration or demonstrable B-BB dysfunction. Brain lead concentrations increased over the 5-day period. The encephalopathy in the absence of any vascular alteration suggests that lead can produce a primary toxic effect at the neuronal level.

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