doi: 10.1016/s0960-894x(02)00318-9.
Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues
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- PMID: 12113818
- DOI: 10.1016/s0960-894x(02)00318-9
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Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues
Bioorg Med Chem Lett.
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Abstract
The synthesis and biological evaluation of new diadenosine polyphosphate analogues on blood platelet aggregation are reported. The most active are compounds with a sulfur atom replacing one or both non-bridging oxygens at phosphorus bound to adenosyl residues and hydroxymethyl groups of bis(hydroxymethyl)phosphinic acid.
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