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. 2002 Aug 5;12(15):1959-62.
doi: 10.1016/s0960-894x(02)00318-9.

Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues

Bogdan Walkowiak  1 , Janina Baraniak, Czeslaw S Cierniewski, Wojciech Stec
Affiliations

Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues

Bogdan Walkowiak et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and biological evaluation of new diadenosine polyphosphate analogues on blood platelet aggregation are reported. The most active are compounds with a sulfur atom replacing one or both non-bridging oxygens at phosphorus bound to adenosyl residues and hydroxymethyl groups of bis(hydroxymethyl)phosphinic acid.

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