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. 1999 Winter;10(4):269-281.
doi: 10.1007/BF02739769.

Human Insulinomas: Clinical, Cellular, and Molecular Aspects

Paul Komminoth  1 , Philipp U. Heitz, Jürgen Roth
Affiliations
Free article

Human Insulinomas: Clinical, Cellular, and Molecular Aspects

Paul Komminoth et al. Endocr Pathol. 1999 Winter.
Free article

Abstract

Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B-cells, discuss the new classification, the criteria of malignancy, and the clonal composition of endocrine pancreatic tumors, and outline recent findings on the molecular pathology of these tumors.

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