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Review
. 2002 Aug;70(8):3985-93.
doi: 10.1128/IAI.70.8.3985-3993.2002.

Bacteriophage control of bacterial virulence

Patrick L Wagner  1 , Matthew K Waldor
Affiliations
Review

Bacteriophage control of bacterial virulence

Patrick L Wagner et al. Infect Immun. 2002 Aug.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Phage control of Stx production and release by E. coli. (Top) A partial map (not to scale) of an integrated Stx-encoding prophage is shown. Transcription from phage promoters is limited both by direct phage repressor activity at pL and pR and by transcriptional terminators (downstream of pL, pR, and pR′). Following prophage induction, repressor cleavage allows for increased transcription from pL and pR and production of antiterminators N and Q. These proteins facilitate transcription initiated at pR and pR′, respectively, by allowing readthrough at several terminators, including tL, tR1, and tR′. (Bottom) Both the pR and pR′ promoters, as well as the toxin-associated promoter (pStx) can contribute directly to stx transcription following prophage induction. Additionally, the phage replication gene products (O and P) contribute to Stx production by amplifying stx copy numbers. The phage lysis gene products set a limit on the duration of Stx production and provide a mechanism of toxin release from the cell (97).
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