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. 2002 Aug;46(8):2723-6.
doi: 10.1128/AAC.46.8.2723-2726.2002.

Hematologic effects of linezolid: summary of clinical experience

Stanton L Gerson  1 , Sheldon L Kaplan, Jon B Bruss, Vu Le, Felix M Arellano, Barry Hafkin, David J Kuter
Affiliations

Hematologic effects of linezolid: summary of clinical experience

Stanton L Gerson et al. Antimicrob Agents Chemother. 2002 Aug.

Abstract

Linezolid has been associated with reversible myelosuppression. Clinical trial data were evaluated for anemia, thrombocytopenia, and neutropenia. Thrombocytopenia and a slight increased risk for anemia were evident at > or =2 weeks of linezolid treatment. Hematologic abnormalities were consistent with mild, reversible, duration-dependent myelosuppression. Appropriate monitoring is warranted with linezolid use.

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Figures

FIG. 1.
FIG. 1.
Patients with at least one substantially low PLTC, hemoglobin value, or neutrophil count in linezolid and comparator groups—cumulative percentage over time.
See this image and copyright information in PMC

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