Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Sep;150(3):565-7.
doi: 10.1042/bj1500565.

An 18O double-labelling study of haemoglobin catabolism in the rat

S B Brown, R F King

An 18O double-labelling study of haemoglobin catabolism in the rat

S B Brown et al. Biochem J. 1975 Sep.

Abstract

The degradation of haemoglobin to bilirubin in the rat was investigated by 18O labelling of the molecular oxygen consumed by the animal. The oxygen atoms incorporated into bilirubin were derived from two different oxygen molecules. Implications of this finding for the mechanism of haem catabolism in vivo are discussed; both verdohaem and a dioxygen-bridged compound appear to be excluded at intermediates.

PubMed Disclaimer

References

    1. Essays Biochem. 1972;8:107-48 - PubMed
    1. Biochem J. 1972 Sep;129(3):797-800 - PubMed
    1. J Clin Invest. 1961 Aug;40:1442-52 - PubMed
    1. Biochemistry. 1972 Apr 25;11(9):1716-20 - PubMed
    1. J Clin Invest. 1962 Aug;41:1628-37 - PubMed