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. 1975 Sep;31(1):51-5.
doi: 10.1111/j.1365-2141.1975.tb00831.x.

Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets

M J Broekman, R I Handin, P Cohen

Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets

M J Broekman et al. Br J Haematol. 1975 Sep.

Abstract

The distribution of fibrinogen, platelet factor 4 (heparin-neutralizing factor) and factor XIII amongst subcellular fractions of human platelets was determined. It was found that fibrinogen and platelet factor 4 peaked sharply in the region of the density gradient previously shown to be heavily enriched with alpha-granules. By contrast, factor XIII, fibrin-stabilizing factor, was found exclusively in the supernatant.

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