Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Oct 28;184(2):165-70.
doi: 10.1016/s0304-3835(02)00210-0.

Intravenous anesthetic, propofol inhibits invasion of cancer cells

Tadanori Mammoto  1 , Mutsuko Mukai, Akiko Mammoto, Yasutsugu Yamanaka, Yukio Hayashi, Takashi Mashimo, Yoshihiko Kishi, Hiroyuki Nakamura
Affiliations

Intravenous anesthetic, propofol inhibits invasion of cancer cells

Tadanori Mammoto et al. Cancer Lett. .

Abstract

Intravenous anesthetic, propofol (2,6-diisopropylphenol), is extensively used for general anesthesia without knowing the effects on cancer. We found here that clinically relevant concentrations of propofol (1-5 microg/ml) decreased the invasion ability of human cancer cells (HeLa, HT1080, HOS and RPMI-7951). In the HeLa cells treated with propofol, formation of actin stress fibers as well as focal adhesion were inhibited, and propofol had little effect on the invasion ability of the HeLa cells with active Rho A (Val(14)-Rho A). In addition, continuous infusion of propofol inhibited pulmonary metastasis of murine osteosarcoma (LM 8) cells in mice. These results suggest that propofol inhibits the invasion ability of cancer cells by modulating Rho A and this agent might be an ideal anesthetic for cancer surgery.

PubMed Disclaimer

LinkOut - more resources