Review
doi: 10.1016/s0166-2236(02)02207-5.
Sealed with a twist: complexin and the synaptic SNARE complex
Affiliations
- PMID: 12127744
- DOI: 10.1016/s0166-2236(02)02207-5
Item in Clipboard
Review
Sealed with a twist: complexin and the synaptic SNARE complex
Trends Neurosci.
2002 Aug.
Abstract
Knockout experiments show that complexins are crucial for Ca(2+)-dependent neurotransmitter release. In the recently solved crystal structure of complexin I bound to the synaptic SNARE complex, complexin binds along the groove between the syntaxin and synaptobrevin coils. This structure, together with NMR data, suggests that the role of complexin is to stabilize the SNARE complex as it forms from SNAREs in vesicle and target membranes.
Similar articles
-
Snares and Munc18 in synaptic vesicle fusion.Nat Rev Neurosci. 2002 Aug;3(8):641-53. doi: 10.1038/nrn898. Nat Rev Neurosci. 2002. PMID: 12154365 Review. No abstract available.
-
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.Cell. 2006 Sep 22;126(6):1175-87. doi: 10.1016/j.cell.2006.08.030. Cell. 2006. PMID: 16990140
-
Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.Mol Cell Neurosci. 2002 Jun;20(2):169-80. doi: 10.1006/mcne.2002.1122. Mol Cell Neurosci. 2002. PMID: 12093152
-
Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease.Brain Res Bull. 2001 Sep 15;56(2):111-7. doi: 10.1016/s0361-9230(01)00611-6. Brain Res Bull. 2001. PMID: 11704347
-
Synaptic vesicle fusion and synaptotagmin: 2B or not 2B?Nat Neurosci. 2002 Sep;5(9):823-4. doi: 10.1038/nn0902-823. Nat Neurosci. 2002. PMID: 12196805 Review. No abstract available.
Cited by
-
Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus.Psychopharmacology (Berl). 2005 Sep;181(3):560-5. doi: 10.1007/s00213-005-0017-4. Epub 2005 Oct 12. Psychopharmacology (Berl). 2005. PMID: 15983795
-
Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide.Neurobiol Learn Mem. 2006 Jan;85(1):2-15. doi: 10.1016/j.nlm.2005.08.014. Epub 2005 Oct 14. Neurobiol Learn Mem. 2006. PMID: 16230036 Free PMC article. Review.
-
Tag team action at the synapse.EMBO Rep. 2007 Sep;8(9):834-8. doi: 10.1038/sj.embor.7401051. EMBO Rep. 2007. PMID: 17767192 Free PMC article. Review.
-
Single-molecule studies of synaptotagmin and complexin binding to the SNARE complex.Biophys J. 2005 Jul;89(1):690-702. doi: 10.1529/biophysj.104.054064. Epub 2005 Apr 8. Biophys J. 2005. PMID: 15821166 Free PMC article.
-
An electrostatically preferred lateral orientation of SNARE complex suggests novel mechanisms for driving membrane fusion.PLoS One. 2010 Jan 26;5(1):e8900. doi: 10.1371/journal.pone.0008900. PLoS One. 2010. PMID: 20126653 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
