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. 2002 Jul 19;297(5580):409-12.
doi: 10.1126/science.1071632.

Integrin-mediated long-term B cell retention in the splenic marginal zone

Theresa T Lu  1 , Jason G Cyster
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Integrin-mediated long-term B cell retention in the splenic marginal zone

Theresa T Lu et al. Science. .

Abstract

The mechanisms that control localization of marginal zone (MZ) B cells are poorly understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 (alphaLbeta2) and alpha4beta1 and that they bind to the ligands ICAM-1 and VCAM-1. These ligands are expressed within the MZ in a lymphotoxin-dependent manner. Combined inhibition of LFA-1 and alpha4beta1 causes a rapid and selective release of B cells from the MZ. Furthermore, lipopolysaccharide-triggered MZ B cell relocalization involves down-regulation of integrin-mediated adhesion. These studies identify key requirements for MZ B cell localization and establish a role for integrins in peripheral lymphoid tissue compartmentalization.

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