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Review
. 2002 Aug;6(4):447-52.
doi: 10.1016/s1367-5931(02)00341-1.

Protein flexibility and drug design: how to hit a moving target

Heather A Carlson  1
Affiliations
Review

Protein flexibility and drug design: how to hit a moving target

Heather A Carlson. Curr Opin Chem Biol. 2002 Aug.

Abstract

The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.

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