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. 1975;6(6):337-41.
doi: 10.1159/000301532.

Experimental production of aneuploidy in mouse oocytes

L E Karp, W D Smith

Experimental production of aneuploidy in mouse oocytes

L E Karp et al. Gynecol Invest. 1975.

Abstract

The normal course of meiosis can be interrupted in cultured mouse oocytes by exposre to low temperature (23 degrees C). Re-transfer of the oocytes to a 37 degrees C environment will permit the meiotic process to resume and progress as usual to second metaphase. However, a significant number of oocytes treated in this manner prove to contain abnormal numbers of chromosomes.

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