[Nephrotic syndrome in minimal change disease (kidney), focal segmental glomerulosclerosis, and focal mesangioproliferative glomerulonephritis]
- PMID: 12136479
[Nephrotic syndrome in minimal change disease (kidney), focal segmental glomerulosclerosis, and focal mesangioproliferative glomerulonephritis]
Abstract
Aim: To specify clinical and laboratory characteristics of minimal change disease (MCD), focal mesangioproliferative glomerulonephritis (MPGN), focal-segmental glomerulosclerosis (FSGS).
Material and methods: A retrospective analysis of 45 case histories of children (renal biopsy for nephrotic syndrome) has shown that morphologically 13 of them had MCD, 15--FSGS and 17--focal MPGN. Clinical, laboratory, immunofluorescent and electron microscopy findings typical for each of the morphological types were studied.
Results: The data obtained suggest that MCD, FSGS and focal MPGN may represent independent forms of glomerulonephritis.
Conclusion: If a differential diagnosis by renal biopsy is difficult, information from the disease history and clinico-laboratory evidence should be used.
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