Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2002 Jul;76(1):91-3.
doi: 10.1007/BF02982725.

Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

Yasunobu Abe  1 , Shinji Yashiki, Ilseung Choi, Keiichi Hara, Takamitsu Matsushima, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta
Affiliations
Case Reports

Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

Yasunobu Abe et al. Int J Hematol. 2002 Jul.

Abstract

We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelosuppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270. This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.

PubMed Disclaimer

References

    1. Bone Marrow Transplant. 1987 Dec;2(4):441-4 - PubMed
    1. Leukemia. 1994 Apr;8 Suppl 1:S54-9 - PubMed
    1. Nature. 1990 Nov 15;348(6298):245-8 - PubMed
    1. J Virol. 2000 Oct;74(20):9610-6 - PubMed
    1. Blood. 2001 Dec 15;98(13):3595-9 - PubMed

Publication types

MeSH terms

LinkOut - more resources