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Case Reports
. 2002 Aug;8(8):852-4.
doi: 10.3201/eid0808.010448.

Genetic detection and isolation of crimean-congo hemorrhagic fever virus, Kosovo, Yugoslavia

Anna Papa  1 , Bojana Bozovi, Vassiliki Pavlidou, Evangelia Papadimitriou, Mijomir Pelemis, Aantonis Antoniadis
Affiliations
Case Reports

Genetic detection and isolation of crimean-congo hemorrhagic fever virus, Kosovo, Yugoslavia

Anna Papa et al. Emerg Infect Dis. 2002 Aug.

Abstract

Crimean-Congo hemorrhagic fever virus (C-CHFV) strains were isolated from a fatal case and the attending physician in Kosovo, Yugoslavia. Early, rapid diagnosis of the disease was achieved by reverse transcription-polymerase chain reaction. The physician was successfully treated with oral ribavirin. These cases yielded the first genetically studied C-CHFV human isolates in the Balkans.

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Figures

Figure
Figure
Phylogenetic relationships based on 255-nt fragment from the small RNA segment between sequences obtained from this study and respective representative Crimean-Congo hemorrhagic fever strains from GenBank. In the phylogenetic tree, sequences of other two nairoviruses, Dugbe and Hazara, were included; Hazara virus was used as outgroup. The numbers indicate percentage bootstrap replicates (of 100) calculated by using SEQBOOT, DNADIST, FITCH, and CONSENSE from the PHYLIP package ; values <70% are not shown. Horizontal distances are proportional to the nucleotide differences. The scale bar indicates 10% nucleotide sequence divergence. Vertical distances are for clarity only.
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References

    1. Gligić A, Stamatović L, Stojanović R, Obradović M, Bošković R. Prva izolacija virusa krimske hemoragične groznice u Jugoslaviji. [The first isolation of the Crimean hemorraghic fever virus in Yugoslavia]. Vojnosanit Pregl. 1977;34:318–21. - PubMed
    1. World Health Organization. Crimean-Congo haemorrhagic fever (C-CHF) in Kosovo – update 5. 29 June 2001. Available from: URL: http://www.who.int/disease-outbreak-news/n2001/june/29june2001.html
    1. Lennette EH, Schmidt NJ. Diagnostic procedures. 4th ed. New York: American Public Health Association, Inc.;1969. p. 304.
    1. Schwarz TF, Nsanze H, Longson M, Nitschko H, Gilch S, Shurie H, et al. Polymerase chain reaction for diagnosis and identification of distinct variants of Crimean-Congo hemorrhagic fever virus in the United Arab Emirates. Am J Trop Med Hyg. 1996;55:190–6. - PubMed
    1. Swanepoel R, Leham P, Abbott JC, Burt FJ, Grobbelaar AA. Epidemiology, diagnosis, clinical pathology and treatment of Crimean-Congo hemorrhagic fever (CCHF) in South Africa. Proceedings and Abstracts of the VIIth International Congress of Virology, Berlin, 1990.

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