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. 2002 Jul 26;297(5581):620-3.
doi: 10.1126/science.1072810.

Identification of Bphs, an autoimmune disease locus, as histamine receptor H1

Runlin Z Ma  1 , Jianfeng Gao, Nathan D Meeker, Parley D Fillmore, Kenneth S K Tung, Takeshi Watanabe, James F Zachary, Halina Offner, Elizabeth P Blankenhorn, Cory Teuscher
Affiliations

Identification of Bphs, an autoimmune disease locus, as histamine receptor H1

Runlin Z Ma et al. Science. .

Abstract

Bphs controls Bordetella pertussis toxin (PTX)-induced vasoactive amine sensitization elicited by histamine (VAASH) and has an established role in autoimmunity. We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice. Hrh1-/- mice are protected from VAASH, which can be restored by genetic complementation with a susceptible Bphs/Hrh1 allele, and experimental allergic encephalomyelitis and autoimmune orchitis due to immune deviation. Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTX sensitization.

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