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. 2002 Jul;68(7):647-9.
doi: 10.1055/s-2002-32903.

ent-trachyloban-3beta-ol, a new cytotoxic diterpene from Croton zambesicus

S Block, C Stévigny, M-C De Pauw-Gillet, E de Hoffmann, G Llabrès, V Adjakidjé, J Quetin-Leclercq

ent-trachyloban-3beta-ol, a new cytotoxic diterpene from Croton zambesicus

S Block et al. Planta Med. 2002 Jul.

Abstract

The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 microg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.

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