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. 1975 Dec;53(6):456-61.

Immunogenicity of inactivated influenza vaccine, purified by adsorption chromatography on porous glas

S Bresler, V Kolikov, N Katushkina, V Molodkin, E Friedman, H Zheleznova, L Malafeieva, T Peradze, V Beljakov, K Ivanov
  • PMID: 1214539

Immunogenicity of inactivated influenza vaccine, purified by adsorption chromatography on porous glas

S Bresler et al. Med Biol. 1975 Dec.

Abstract

A chromatographic process has been developed for a mass purification and concentration of influenza virus. The final virus suspension, purified some 400 times, is characterized by its antigenic properties and protein content. The virus was killed by UV-light and the resulting vaccine tried on 345 people. The immunity level is 8 times higher than the control. In mice which were infected after immunization with a homologous and heterologous influenza virus strains a high protection index was found (10(6) EID50 for homologous and 10(4) EID50 for heterologous strains).

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