Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice
- PMID: 12145526
- DOI: 10.1007/BF02256584
Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice
Abstract
Acute administration of absolute ethanol (10 ml/kg) per os to fasted mice produced extensive renal failure as measured by a rise in blood urea nitrogen and creatinine. Pretreatment with oral administration of tetramethylpyrazine (TMP) prevented such failure. The maximal effect against absolute ethanol-induced renal failure could be observed 1 h after TMP administration. In order to further investigate the renal protective mechanism of TMP, experiments on lipid peroxidation and superoxide scavenging activity were conducted. Renal homogenates made from mice treated with ethanol showed that TMP pretreatment had an antioxidant effect. Mice in acute renal failure had higher malonic dialdehyde concentrations than those pretreated with TMP. The renal protective mechanism of TMP was attributed, in part, to its prominent superoxide scavenging effect, which protects the kidney from superoxide-induced renal damage.
Copyright 2002 National Science Council, ROC and S. Karger AG, Basel
Similar articles
-
Antioxidative effects of tetramethylpyrazine on acute ethanol-induced lipid peroxidation.Am J Chin Med. 2005;33(6):981-8. doi: 10.1142/S0192415X05003570. Am J Chin Med. 2005. PMID: 16355454
-
Protection by tetramethylpyrazine in acute absolute ethanol-induced gastric lesions.J Biomed Sci. 2002 Sep-Oct;9(5):395-400. doi: 10.1007/BF02256532. J Biomed Sci. 2002. PMID: 12218353
-
Protective effect of propolis ethanol extract on ethanol-induced renal toxicity: an in-vivo study.Am J Chin Med. 2005;33(5):779-86. doi: 10.1142/S0192415X05003363. Am J Chin Med. 2005. PMID: 16265990
-
Nephroprotective effect of calcium channel blockers against toxicity of lead exposure in mice.Toxicol Lett. 2013 Apr 26;218(3):273-80. doi: 10.1016/j.toxlet.2013.02.005. Epub 2013 Feb 18. Toxicol Lett. 2013. PMID: 23428833
-
Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi.Exp Biol Med (Maywood). 2008 Jul;233(7):891-6. doi: 10.3181/0711-RM-315. Epub 2008 Apr 29. Exp Biol Med (Maywood). 2008. PMID: 18445776
Cited by
-
Ligustrazine protects against chronic hypertensive glaucoma in rats by inhibiting autophagy via the PI3K-Akt/mTOR pathway.Mol Vis. 2021 Dec 12;27:725-733. eCollection 2021. Mol Vis. 2021. PMID: 35035207 Free PMC article.
-
Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.World J Gastroenterol. 2003 Jul;9(7):1563-6. doi: 10.3748/wjg.v9.i7.1563. World J Gastroenterol. 2003. PMID: 12854164 Free PMC article.
-
Bidirectional negative relationship between thyrotropin and kidney function during alcohol intoxication in males.Front Nephrol. 2024 Aug 8;4:1322791. doi: 10.3389/fneph.2024.1322791. eCollection 2024. Front Nephrol. 2024. PMID: 39175745 Free PMC article.
-
Effects of Z-FA.FMK on D-galactosamine/tumor necrosis factor-alpha-induced kidney injury and oxidative stress in mice : effects of Z-FA.FMK on TNF-alpha-mediated kidney injury.Mol Cell Biochem. 2008 Feb;309(1-2):9-20. doi: 10.1007/s11010-007-9636-x. Epub 2007 Nov 16. Mol Cell Biochem. 2008. PMID: 18008146
-
Tetramethylpyrazine: An Active Ingredient of Chinese Herbal Medicine With Therapeutic Potential in Acute Kidney Injury and Renal Fibrosis.Front Pharmacol. 2022 Jan 25;13:820071. doi: 10.3389/fphar.2022.820071. eCollection 2022. Front Pharmacol. 2022. PMID: 35145414 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Medical