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. 2002 Jul;12(3):300-7.
doi: 10.1111/j.1750-3639.2002.tb00444.x.

Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease

John M Woulfe  1 , Robert Hammond, Bryan Richardson, Danushan Sooriabalan, William Parks, Peter Rippstein, David G Munoz
Affiliations

Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease

John M Woulfe et al. Brain Pathol. 2002 Jul.

Abstract

Neuronal intranuclear rodlets were described in normal brain over a century ago, but their functional significance and pathological relevance is unknown. Here, we show co-localization of tubulin and glucocorticoid receptor-like immunoreactivity in these intranuclear inclusions in human brain. In addition, we provide evidence for a massive reduction in their areal density in Alzheimer's disease brain, but not in another common neurodegenerative condition, dementia with Lewy bodies. The marked reduction of these inclusions in Alzheimer's disease may support the concept of a role for stress hormones in Alzheimer's pathogenesis.

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References

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