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Review
. 2002 Aug;55(8):569-74.
doi: 10.1136/jcp.55.8.569.

Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast

A Rice  1 , C M Quinn
Affiliations
Review

Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast

A Rice et al. J Clin Pathol. 2002 Aug.

Abstract

Angiogenesis, the growth of new vessels from existing vasculature, plays an essential role in tumour development. The process involves interaction between a variety of cells, growth factors, and components of the extracellular matrix, regulated by pro-angiogenic and anti-angiogenic factors. This review profiles these factors, outlines the available methods for measuring new vessel formation, and discusses the importance of angiogenesis in breast cancer, with emphasis on ductal carcinoma in situ.

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