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Case Reports
. 2002 Aug;40(8):2750-4.
doi: 10.1128/JCM.40.8.2750-2754.2002.

Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting

Madalene Richardson  1 , Nora M Carroll, Erica Engelke, Gian D Van Der Spuy, Faeeza Salker, Zahn Munch, Robert P Gie, Robin M Warren, Nulda Beyers, Paul D Van Helden
Affiliations
Case Reports

Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting

Madalene Richardson et al. J Clin Microbiol. 2002 Aug.

Abstract

In an ongoing molecular epidemiology study, human immunodeficiency virus-negative patients with first-time pulmonary tuberculosis from a high-incidence community were enrolled. Mycobacterium tuberculosis strains were identified by restriction fragment length polymorphism analysis with two fingerprinting probes. Of 131 patients, 3 (2.3%) were shown to have a mixture of strains in one or two of their serial cultures. This study further investigated these cases with disease caused by multiple M. tuberculosis strains in the context of the molecular epidemiology of the study setting.

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Figures

FIG. 1.
FIG. 1.
(A) IS6110-3′ RFLP patterns for the mixed and follow-up cultures of three patients as well as the initial infecting and relapse strains isolated (and confirmed by serial culture) from the husband of patient 2. (B) DRr RFLP patterns generated by cultures from three patients with mixed-strain cultures, where the mixture of strains is indicated by the DR patterns of two strains. The arrows indicate low-intensity DR bands. Diag, diagnosis; D, day; W, week.
See this image and copyright information in PMC

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