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Review
. 2002 Aug 6;99(16):10243-5.
doi: 10.1073/pnas.172384299. Epub 2002 Jul 30.

Imprinted gene expression, transplantation medicine, and the "other" human embryonic stem cell

Carmen Sapienza  1
Affiliations
Review

Imprinted gene expression, transplantation medicine, and the "other" human embryonic stem cell

Carmen Sapienza. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig 1.
Fig 1.
Magnitude of epigenetic differences between maternal and paternal genomes as a function of germ cell development and transition to early embryonic development. Genome imprints in migratory primordial germ cells appear largely intact but distinguishing features between maternal and paternal genomes, such as differential DNA methylation, begin to be degraded by the time primordial germ cells colonize the genital ridge. Distinctions continue to disappear throughout proliferation, although some distinctions remain even as the germ cells withdraw from the mitotic cycle and enter meiosis. Different genome modifications are reestablished during male and female gametogenesis and these differences are, presumably, sufficient by the time of pronuclear fusion in the zygote to program any additional modifications that are required to result in imprinted gene expression. The y axis scale is arbitrary. Times on the x axis are for mouse development. Horizontal arrows above the graph indicate the periods at which EG and ES cells are derived. Vertical arrow at the right side of the graph represents the “epigenetic instability” observed in mouse ES cells.
See this image and copyright information in PMC

Comment on

References

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