doi: 10.1136/pgmj.51.595.344.
The cardiomyopathy associated with methylsalicylate
- PMID: 1215248
- PMCID: PMC2495986
- DOI: 10.1136/pgmj.51.595.344
Item in Clipboard
The cardiomyopathy associated with methylsalicylate
Postgrad Med J.
1975 May.
Abstract
Dogs challenged with toxic doses of methylsalicylate developed acute myocardiopathy. Metabolic manifestations of uncoupling of oxidative phosphorylation by methylsalicylate (MS) were observed. Oxygen consumption increased two-fold. The haemodynamic abnormalities produced by intervention were minimal. The measured metabolic parameters indicated profound derangement. A net efflux of orthophosphate, lactate and potassium was observed from the myocardium. Marked hyperkalaemia occurred terminally. Morphological changes were observed on electron microscopy.
Similar articles
-
Acute hyperkalemic cardiomyopathy in the dog.Recent Adv Stud Cardiac Struct Metab. 1972;1:579-87. Recent Adv Stud Cardiac Struct Metab. 1972. PMID: 4681484 No abstract available.
-
Methylsalicylate myopathy in man.East Afr Med J. 1971 Dec;48(12):735-40. East Afr Med J. 1971. PMID: 5148606 No abstract available.
-
Cardiac glutathione: diurnal rhythm and variation in drug-induced cardiomyopathy.Res Commun Chem Pathol Pharmacol. 1979 Apr;24(1):27-36. Res Commun Chem Pathol Pharmacol. 1979. PMID: 571131 No abstract available.
-
Fragrance material review on methyl 4-methylsalicylate.Food Chem Toxicol. 2007;45 Suppl 1:S457-9. doi: 10.1016/j.fct.2007.09.050. Epub 2007 Sep 14. Food Chem Toxicol. 2007. PMID: 18022305 Review.
-
Toxic agents and cardiomyopathies.Cardiovasc Clin. 1972;4(1):245-67. Cardiovasc Clin. 1972. PMID: 4568939 Review. No abstract available.
