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Comparative Study
. 2002 Aug 3;325(7358):243.
doi: 10.1136/bmj.325.7358.243.

Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study

Carol E Koro  1 , Donald O Fedder, Gilbert J L'Italien, Sheila S Weiss, Laurence S Magder, Julie Kreyenbuhl, Dennis A Revicki, Robert W Buchanan
Affiliations
Comparative Study

Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study

Carol E Koro et al. BMJ. .

Abstract

Objective: To quantify the association between olanzapine and diabetes.

Design: Population based nested case-control study.

Setting: United Kingdom based General Practice Research Database comprising 3.5 million patients followed between 1987 and 2000.

Participants: 19 637 patients who had been diagnosed as having and treated for schizophrenia. 451 incident cases of diabetes were matched with 2696 controls.

Main outcome measures: Diagnosis and treatment of diabetes.

Results: Patients taking olanzapine had a significantly increased risk of developing diabetes than non-users of antipsychotics (odds ratio 5.8, 95% confidence interval 2.0 to 16.7) and those taking conventional antipsychotics (4.2, 1.5 to 12.2). Patients taking risperidone had a non-significant increased risk of developing diabetes than non-users of antipsychotics (2.2, 0.9 to 5.2) and those taking conventional antipsychotics (1.6, 0.7 to 3.8).

Conclusion: Olanzapine is associated with a clinically important and significant increased risk of diabetes.

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