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Review
. 2002 Aug;3(8):619-25.
doi: 10.1038/nrm880.

What messenger RNA capping tells us about eukaryotic evolution

Stewart Shuman
Review

What messenger RNA capping tells us about eukaryotic evolution

Stewart Shuman. Nat Rev Mol Cell Biol. 2002 Aug.

Abstract

The 5' cap is a unique feature of eukaryotic cellular and viral messenger RNA that is absent from the bacterial and archaeal domains of life. The cap is formed by three enzymatic reactions at the 5' terminus of nascent mRNAs. Although the capping pathway is conserved in all eukaryotes, the structure and genetic organization of the component enzymes vary between species. These differences provide insights into the evolution of eukaryotes and eukaryotic viruses.

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