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. 2002 Jun;88(6):686-98.

[Peptide-protein complexes of angiotensins in the mechanisms of thirst]

[Article in Russian]
A V Kotov  1 , S M Tolpygo, E I Pevtsova, M F Obukhova
Affiliations
  • PMID: 12154565

[Peptide-protein complexes of angiotensins in the mechanisms of thirst]

[Article in Russian]
A V Kotov et al. Ross Fiziol Zh Im I M Sechenova. 2002 Jun.

Abstract

The comparative analysis of learned and natural drinking behavior under native angiotensin-I (A-I), angiotensin-II (A-II) and its protein-peptides complexes (PPC) administration in rats, was performed. Various effects of these substances on drinking behavior were observed. PPC of A-I became a dipsogenic agent as compared with the native one. Moreover, PPC of A-II facilitated selectively learned and not natural forms of drinking behavior. It's suggested that PPC of angiotensins play a specific role in endogenous mechanisms of thirst. An important function of this complexes due to their conformational properties and participation in realization of basic needs, is discussed.

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