Review
Wiskott-Aldrich syndrome (role of WASP)
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- PMID: 12160237
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Review
Wiskott-Aldrich syndrome (role of WASP)
J Med Dent Sci.
2001 Mar.
Abstract
Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by thrombocytopenia, eczema and immunodeficiency. WASP, the gene responsible for WAS, has been identified by positional cloning, contains a PH domain, a GBD domain, a proline rich region, and a verprolin/cofilin homology domain. Subsequent studies suggest that WASP is involved in signal transduction and in the regulation of the cytoskeleton.
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