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. 2002 Aug 2;297(5582):854-7.
doi: 10.1126/science.1071506.

Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina

Walter Muranyi  1 , Jürgen Haas, Markus Wagner, Georg Krohne, Ulrich H Koszinowski
Affiliations

Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina

Walter Muranyi et al. Science. .

Abstract

The passage of large-sized herpesviral capsids through the nuclear lamina and the inner nuclear membrane to leave the nucleus requires a dissolution of the nuclear lamina. Here, we report on the functions of M50/p35, a beta-herpesviral protein of murine cytomegalovirus. M50/p35 inserts into the inner nuclear membrane and is aggregated by a second viral protein, M53/p38, to form the capsid docking site. M50/p35 recruits the cellular protein kinase C for phosphorylation and dissolution of the nuclear lamina, suggesting that herpesviruses target a critical element of nuclear architecture.

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Comment in

  • Virology. CMV makes a timely exit.
    Sanchez V, Spector DH. Sanchez V, et al. Science. 2002 Aug 2;297(5582):778-9. doi: 10.1126/science.1075102. Science. 2002. PMID: 12161637 No abstract available.

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