Insights into lipid raft structure and formation from experiments in model membranes

Abstract

Rafts are sphingolipid/cholesterol-rich lipid domains believed to exist within certain eukaryotic cell membranes. Model membrane studies have been key to understanding the basic physical principles behind raft formation. Recent fluorescence quenching studies have demonstrated that tight packing between sterols and sphingolipids is the driving force for raft formation, and have begun to decipher the rules governing how different molecules interact with rafts.