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. 2002 Aug;73(5):434-8.
doi: 10.1016/s0367-326x(02)00124-7.

Antimicrobial diterpenes from the stem bark of Mitrephora celebica

J R Zgoda-Pols  1 , A J Freyer, L B Killmer, J R Porter
Affiliations

Antimicrobial diterpenes from the stem bark of Mitrephora celebica

J R Zgoda-Pols et al. Fitoterapia. 2002 Aug.

Abstract

Four diterpenes were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Ent-trachyloban-19-oic acid (1) and ent-kaur-16-en-19-oic acid (2) were identified as the compounds responsible for the antimicrobial activity of the plant against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis. 8(14),15-pimaradien-18-oic acid (3) and 7,15-pimaradien-18-oic acid (4) were isolated from the same fraction and were inactive against the microorganisms.

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