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Case Reports
. 2002 Jul 1;136(1):62-5.
doi: 10.1016/s0165-4608(01)00664-1.

Cytogenetic abnormalities in a hemangiopericytoma of the spleen

Magnus Hallén  1 , Luis A Parada, Ludmila Gorunova, Birger Pålsson, Michael Dictor, Bertil Johansson
Affiliations
Case Reports

Cytogenetic abnormalities in a hemangiopericytoma of the spleen

Magnus Hallén et al. Cancer Genet Cytogenet. .

Abstract

To date, only 16 cytogenetically abnormal hemangiopericytomas (HP) have been reported. Despite this low number, some characteristic karyotypic features have already emerged: most HP are near-diploid and breakpoints in 12q13, 12q24, and 19q13 seem to be common, with t(12;19)(q13;q13) being a recurrent translocation. Here, we report the first case of a probably benign splenic HP with chromosomal abnormalities. The abnormal karyotype was 47,XX,t(5;22;11)(q31;q11;q13),+10. None of these abnormalities have previously been reported in HP, suggesting that the karyotypic pattern of splenic HP may differ from soft tissue HP.

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