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Review
. 2002 Sep;9(18):1655-65.
doi: 10.2174/0929867023369277.

Acridine derivatives as chemotherapeutic agents

William A Denny  1
Affiliations
Review

Acridine derivatives as chemotherapeutic agents

William A Denny. Curr Med Chem. 2002 Sep.

Abstract

Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial and antiprotozoal agents. Some work in these areas continues, but recent research has focused mainly on their use as anticancer drugs, because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase enzymes.

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