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. 2002 Aug 16;16(12):1686-9.
doi: 10.1097/00002030-200208160-00017.

M184V is associated with a low incidence of thymidine analogue mutations and low phenotypic resistance to zidovudine and stavudine

Mounir Ait-Khaled  1 , Chris Stone, Gillian Amphlett, Bonaventura Clotet, Schlomo Staszewski, Christine Katlama, Margaret Tisdale; CNA3002 International Study Team
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M184V is associated with a low incidence of thymidine analogue mutations and low phenotypic resistance to zidovudine and stavudine

Mounir Ait-Khaled et al. AIDS. .

Abstract

The resistance of HIV clinical isolates with or without M184V was analysed in relation to plasma HIV-1-RNA level and time on therapy. The number of thymidine analogue mutations (TAMs) was lower in isolates with M184V, this was independent of plasma HIV-1-RNA level and time on therapy for T215F/Y, D67N and L210W. This suggests a direct effect of M184V on the reduced selection of TAMs. Lamivudine use was significantly associated with lower median fold resistance to zidovudine and stavudine.

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