Review
doi: 10.1097/00125817-200207000-00004.
GJB2 (connexin 26) variants and nonsyndromic sensorineural hearing loss: a HuGE review
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- PMID: 12172392
- DOI: 10.1097/00125817-200207000-00004
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Review
GJB2 (connexin 26) variants and nonsyndromic sensorineural hearing loss: a HuGE review
Genet Med.
2002 Jul-Aug.
Free article
Abstract
Despite the enormous heterogeneity of genetic hearing loss, variants in one locus, Gap Junction Beta 2 or GJB2 (connexin 26), account for up to 50% of cases of nonsyndromic sensorineural hearing loss in some populations. This article reviews genetic epidemiology studies of the alleles of GJB2, prevalence rates, genotype-phenotype relations, contribution to the incidence of hearing loss, and other issues related to the clinical validity of genetic testing for GJB2. This review focuses primarily on three alleles: 167 Delta T, 35 Delta G, and 235 Delta C. These alleles are recessive for nonsyndromic prelingual sensorineural hearing loss, and the evidence suggests complete penetrance but variable expressivity.
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