Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Sep;5(9):837-8.
doi: 10.1038/nn901.

A-kinase anchoring proteins in amygdala are involved in auditory fear memory

Marta A P Moita  1 , Raphael Lamprecht, Karim Nader, Joseph E LeDoux
Affiliations

A-kinase anchoring proteins in amygdala are involved in auditory fear memory

Marta A P Moita et al. Nat Neurosci. 2002 Sep.

Erratum in

  • Nat Neurosci 2002 Oct;5(10):1017

Abstract

A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that bind the regulatory subunits of protein kinase A (PKA). AKAP binding to PKA regulates the phosphorylation of various proteins, some of which have been implicated in synaptic plasticity and memory consolidation. Here we show that the regulatory subunits of PKA are colocalized with AKAP150 (an AKAP isoform that is expressed in the brain) in the lateral amygdala (LA) and that infusion to the LA of the peptide St-Ht31, which blocks PKA anchoring onto AKAPs, impairs memory consolidation of auditory fear conditioning.

PubMed Disclaimer

Publication types

MeSH terms