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Clinical Trial
. 2002 Aug;70(4):887-96.
doi: 10.1037//0022-006x.70.4.887.

Multicenter trial of fluoxetine as an adjunct to behavioral smoking cessation treatment

Raymond Niaura  1 , Bonnie Spring, Belinda Borrelli, Donald Hedeker, Michael G Goldstein, Nancy Keuthen, Judy DePue, Jean Kristeller, Judy Ockene, Allan Prochazka, John A Chiles, David B Abrams
Affiliations
Clinical Trial

Multicenter trial of fluoxetine as an adjunct to behavioral smoking cessation treatment

Raymond Niaura et al. J Consult Clin Psychol. 2002 Aug.

Abstract

The authors evaluated the efficacy of fluoxetine hydrochloride (Prozac; Eli Lilly and Company, Indianapolis, IN) as an adjunct to behavioral treatment for smoking cessation. Sixteen sites randomized 989 smokers to 3 dose conditions: 10 weeks of placebo, 30 mg, or 60 mg fluoxetine per day. Smokers received 9 sessions of individualized cognitive-behavioral therapy, and biologically verified 7-day self-reported abstinence follow-ups were conducted at 1, 3, and 6 months posttreatment. Analyses assuming missing data counted as smoking observed no treatment difference in outcomes. Pattern-mixture analysis that estimates treatment effects in the presence of missing data observed enhanced quit rates associated with both the 60-mg and 30-mg doses. Results support a modest, short-term effect of fluoxetine on smoking cessation and consideration of alternative models for handling missing data.

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References

    1. Anda RF, Williamson DF, Escobedo LG, Mast EE, Giovino GA, Remington PL. Depression and the dynamics of smoking. A national perspective. JAMA. 1990;264:1541–1545. - PubMed
    1. Blondal T, Gudmundsson LJ, Tomasson K, Jonsdottir D, Hilmarsdottir H, Kristjansson F. The effects of fluoxetine combined with nicotine inhalers in smoking cessation—A randomized trial. Addiction. 1999;94:1007–1015. - PubMed
    1. Bowen DJ, Spring B, Fox E. Tryptophan and high-carbohydrate diets as adjuncts to smoking cessation therapy. Journal of Behavioral Medicine. 1991;14:97–110. - PubMed
    1. Centers for Disease Control. Cigarette smoking among adults: United States, 1993. Morbidity and Mortality Weekly Report. 1994;43:925–930. - PubMed
    1. Centers for Disease Control. State-specific prevalence of current cigarette smoking among adults: United States, 1998. Morbidity and Mortality Weekly Report. 1999;48:1034–1039. - PubMed

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