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. 2002 Sep 16;12(18):2561-4.
doi: 10.1016/s0960-894x(02)00481-x.

Dihydroquinolines as novel n-NOS inhibitors

Stefan Jaroch  1 , Peter Hölscher, Hartmut Rehwinkel, Detlev Sülzle, Gerardine Burton, Margrit Hillmann, Fiona M McDonald
Affiliations

Dihydroquinolines as novel n-NOS inhibitors

Stefan Jaroch et al. Bioorg Med Chem Lett. .

Abstract

Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring.

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